Improving IL12 immunotherapy in glioblastoma by targeting the long noncoding RNA INCR1

INCR1 silencing affects more immune evasive pathways than PD-L1. Targeting INCR1 may represent a valid approach to improve the efficacy of IL12 therapy in GBM.

Authors

Josephina A.M.A. Gadet (ORCID: https://orcid.org/0009-0002-0724-385X)
Shikha Saini (ORCID: https://orcid.org/0000-0003-0557-1649)
E. Antonio Chiocca
Marco Mineo (ORCID: https://orcid.org/0000-0001-7608-4579)
Gordon J. Freeman

Institutions

Brigham and Women's Hospital (US)
Harvard University (US)
Dana-Farber Cancer Institute (US)
Amsterdam University Medical Centers (NL)

Publication Details

Journal: Journal of Neuro-Oncology
Published: 2025-03-04
DOI: https://doi.org/10.1007/s11060-025-04978-2
Citations: 3
Primary Topic: Cancer-related molecular mechanisms research
Type: article
Field-Weighted Citation Impact: 2.81

Funders

National Institutes of Health

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article

Improving IL12 immunotherapy in glioblastoma by targeting the long noncoding RNA INCR1

Josephina A.M.A. Gadet, Shikha Saini, E. Antonio Chiocca, Marco Mineo et al.

Mar 4, 2025

3 citations

Journal of Neuro-Oncology

Cancer-related molecular mechanisms research

2.81

article

Improving IL12 immunotherapy in glioblastoma by targeting the long noncoding RNA INCR1

Josephina A.M.A. Gadet, Shikha Saini, E. Antonio Chiocca, Marco Mineo, Gordon J. Freeman

March 4, 2025article en

3 citations

Abstract

INCR1 silencing affects more immune evasive pathways than PD-L1. Targeting INCR1 may represent a valid approach to improve the efficacy of IL12 therapy in GBM.

Journal of Neuro-OncologyVol. 173(1)

Brigham and Women's Hospital (US), Harvard University (US), Dana-Farber Cancer Institute (US), Amsterdam University Medical Centers (NL)

National Institutes of Health

Good health and well-being

Openalex Percentile: Top 11%

Cancer-related molecular mechanisms research

2.81

DOI Open Access PDF OpenAlex

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Improving IL12 immunotherapy in glioblastoma by targeting the long noncoding RNA INCR1 — Josephina A.M.A. Gadet, Shikha Saini, et al. · Journal of Neuro-Oncology (2025) | TGRS Research Map | TGRS