Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines
This study demonstrated that PUFAs, particularly DHA, altered PPARγ promoter methylation and expression, as well as modulated the PPARγ/COX2 axis in CRC cells in a cell type-dependent manner. DHA was more effective than the other PUFAs in regulating PPARγ promoter methylation. Our results highlight the potential clinical use of PUFAs in CRC treatment.
Authors
- Esmaeel Babaeenezhad (ORCID: https://orcid.org/0000-0003-2549-7802)
- Peyman Khosravi
- Mostafa Moradi Sarabi (ORCID: https://orcid.org/0000-0003-3052-6858)
Institutions
- Lorestan University of Medical Sciences (IR)
Publication Details
- Journal
- Genes & Nutrition
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12263-025-00764-x
- Citations
- 2
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 1.61