Transcriptomic profiling identifies ferroptosis and NF-κB signaling involved in α-dimorphecolic acid regulation of microglial inflammation
α-DIPA inhibits microglial inflammation likely through regulating the pathways of the ferroptosis and NF-κB signaling. These results provided preliminary evidence for α-DIPA as a potential therapeutic candidate for neurodegenerative diseases like MS.
Authors
- Xiaolan Zhu (ORCID: https://orcid.org/0000-0002-0499-8045)
- W.H. Wilson Tang (ORCID: https://orcid.org/0000-0002-8335-735X)
- Chao Shan (ORCID: https://orcid.org/0000-0003-2297-0692)
- Peijuan Wang (ORCID: https://orcid.org/0000-0003-3648-1355)
- Fan Yang (ORCID: https://orcid.org/0000-0002-1659-956X)
- Limei Yu (ORCID: https://orcid.org/0000-0002-3377-1202)
- Na Zhao (ORCID: https://orcid.org/0009-0003-7045-936X)
Institutions
- Zunyi Medical University (CN)
- Nantong University (CN)
- Shanghai Institutes for Biological Sciences (CN)
- Second People's Hospital of NanTong (CN)
- Lishui City People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12967-025-06296-7
- Citations
- 9
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 13.67