Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1
Together, our results establish that the SE-RBBP7-LSD1 axis represents a potential therapeutic target for BCa treatment.
Authors
- Xiang Ai
- Ruoding Wang
- Qinwen Pan
- Man Qu
- Yuanyin Xi
- Zihan Sun (ORCID: https://orcid.org/0000-0002-5001-7113)
- Chao Zhang (ORCID: https://orcid.org/0000-0002-1083-6587)
- Minghao Wang
- Ying Hu (ORCID: https://orcid.org/0000-0001-7120-6899)
- Jun Jiang (ORCID: https://orcid.org/0000-0002-0560-8889)
- Peng Tang (ORCID: https://orcid.org/0000-0003-3580-7667)
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Fuling Center Hospital of Chongqing (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12967-025-06270-3
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22