Tumour protein p53-activated lncRNA PGM5-AS1 suppresses lung cancer growth and stemness by targeting R-spondin1 <i>via</i> microRNA-1247-5p
This study conveys that TP53-elevated PGM5-AS1 mediates miR-1247-5p to target RSPO1, thereby inhibiting LC growth and stemness, representing a novel avenue for LC therapy.
Authors
- Xuanqin Wu
- Heng Liu (ORCID: https://orcid.org/0000-0002-7106-1463)
- Hongwei Gu (ORCID: https://orcid.org/0000-0001-9962-4662)
- Geng Chen (ORCID: https://orcid.org/0000-0002-2320-2161)
- Zhongliang Chen (ORCID: https://orcid.org/0000-0002-4129-5787)
- Yang Peng (ORCID: https://orcid.org/0000-0003-2989-053X)
Publication Details
- Journal
- Archives of Physiology and Biochemistry
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1080/13813455.2025.2459318
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87