Impregnation of mesenchymal stem cell conditioned media with wortmannin enhanced its antiproliferative effect in breast cancer cells via PI3K/Akt/mTOR pathway
These findings revealed the promising antiproliferative and antimetastasis effects of combining pan-PI3K/Akt/mTOR inhibitors with MSC-derived-CM in breast cancer via the downregulation of PI3K/AKT/mTOR signaling pathways. Further studies are required to validate this chem-regenerative strategy in cancer treatment.
Authors
- Mai M. El-Keiy
- Saad M. El‐Gendy (ORCID: https://orcid.org/0000-0001-6630-7150)
- Mohamed Hessien
- Doha F. Ismail (ORCID: https://orcid.org/0000-0002-1456-9519)
Institutions
- Cairo University (EG)
- Tanta University (EG)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13104-025-07124-3
- Citations
- 4
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Tanta University