Decoding dengue’s neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model
We defined cellular atlas of dengue encephalitis in mouse model and identified the primary target neuron of dengue virus. In addition, we demonstrated the significant cytotoxic effect of CD8<sup>+</sup> T cell, which leads to apoptosis of neuron and neurological dysfunction of mice. Our study provides a molecular and cellular framework for understanding dengue encephalitis through advanced sequencing technologies. The insights gained serve as a foundation for future investigations into its pathogenesis and the development of targeted therapeutic approaches.
Authors
- Jintao Li (ORCID: https://orcid.org/0000-0003-3637-2386)
- Xiao-Feng Xu (ORCID: https://orcid.org/0009-0002-1650-2737)
- Xiaojia Li
- Minyue Qiu (ORCID: https://orcid.org/0000-0002-7718-3111)
- Minchi Liu
- Yanwen Zhang (ORCID: https://orcid.org/0000-0003-1833-3885)
- Lixin Zhao
- Yue Fan (ORCID: https://orcid.org/0000-0003-2942-3659)
- Hua Dong (ORCID: https://orcid.org/0009-0006-0648-7966)
- Wen Xiao (ORCID: https://orcid.org/0000-0001-6001-7523)
- Yinyin Liang
- Yunkai Zhu
Institutions
- Army Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12974-025-03383-w
- Citations
- 4
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- National Natural Science Foundation of China