Metabolomics-Based Study on the Anticonvulsant Mechanism of Acorus tatarinowii: GABA Transaminase Inhibition Alleviates PTZ-Induced Epilepsy in Rats
These results improved our understanding of epilepsy and ATS treatment, potentially leading to better therapies. The identification of key metabolites and their associated pathways in this study offers potential novel therapeutic targets for epilepsy. By modulating these metabolites, future therapies could be designed to better manage the disorder. Moreover, the insights from network pharmacology can guide the development of more effective antiepileptic drugs, paving the way for improved clinical outcomes for patients.
Authors
- Chengwei Fang
- Jiayan Li (ORCID: https://orcid.org/0009-0000-3436-0483)
- Jiepeng Wang (ORCID: https://orcid.org/0000-0003-1854-4420)
- Liang Chen (ORCID: https://orcid.org/0000-0001-8339-8592)
Institutions
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Metabolites
- Published
- 2025-03-04
- DOI
- https://doi.org/10.3390/metabo15030175
- Citations
- 3
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 7.14
Funders
- National Natural Science Foundation of China