Metabolomics-Based Study on the Anticonvulsant Mechanism of Acorus tatarinowii: GABA Transaminase Inhibition Alleviates PTZ-Induced Epilepsy in Rats

These results improved our understanding of epilepsy and ATS treatment, potentially leading to better therapies. The identification of key metabolites and their associated pathways in this study offers potential novel therapeutic targets for epilepsy. By modulating these metabolites, future therapies could be designed to better manage the disorder. Moreover, the insights from network pharmacology can guide the development of more effective antiepileptic drugs, paving the way for improved clinical outcomes for patients.

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Publication Details

Journal
Metabolites
Published
2025-03-04
DOI
https://doi.org/10.3390/metabo15030175
Citations
3
Primary Topic
Medicinal Plants and Neuroprotection
Type
article
Field-Weighted Citation Impact
7.14

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article

Metabolomics-Based Study on the Anticonvulsant Mechanism of Acorus tatarinowii: GABA Transaminase Inhibition Alleviates PTZ-Induced Epilepsy in Rats

Chengwei Fang, Jiayan Li, Jiepeng Wang, Liang Chen
3 citations
Metabolites
Medicinal Plants and Neuroprotection
7.14
article

Metabolomics-Based Study on the Anticonvulsant Mechanism of Acorus tatarinowii: GABA Transaminase Inhibition Alleviates PTZ-Induced Epilepsy in Rats

Chengwei Fang, Jiayan Li, Jiepeng Wang, Liang Chen
article en
3 citations

Abstract

These results improved our understanding of epilepsy and ATS treatment, potentially leading to better therapies. The identification of key metabolites and their associated pathways in this study offers potential novel therapeutic targets for epilepsy. By modulating these metabolites, future therapies could be designed to better manage the disorder. Moreover, the insights from network pharmacology can guide the development of more effective antiepileptic drugs, paving the way for improved clinical outcomes for patients.

MetabolitesVol. 15(3)
Hebei University of Chinese Medicine (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 4%
Medicinal Plants and Neuroprotection
7.14
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