Molecular subtyping of stage I lung adenocarcinoma via molecular alterations in pre-invasive lesion progression
We successfully revealed two molecularly and prognostically distinct subtypes of stage I LUAD by applying key molecular alterations from AIS/MIA to invasive LUAD progression. Our model may help reliably identify high-risk stage I patients for more intensive post-surgery treatment.
Authors
- Yuanting Zheng (ORCID: https://orcid.org/0000-0003-4480-8303)
- Jiang He (ORCID: https://orcid.org/0000-0001-7600-4604)
- Qingwang Chen (ORCID: https://orcid.org/0000-0002-7191-5801)
- Leming Shi (ORCID: https://orcid.org/0000-0002-2981-4150)
- Naixin Zhang (ORCID: https://orcid.org/0000-0001-6683-417X)
- Yingyan Yu (ORCID: https://orcid.org/0000-0002-3585-3252)
- Luyao Ren (ORCID: https://orcid.org/0000-0002-4052-1148)
- Yuan Li (ORCID: https://orcid.org/0000-0002-6466-7774)
- Jingcheng Yang (ORCID: https://orcid.org/0000-0002-2550-3910)
- Yicong Lin (ORCID: https://orcid.org/0000-0002-3994-4637)
- Jun Shang (ORCID: https://orcid.org/0000-0002-5767-1492)
- Yue Zhao (ORCID: https://orcid.org/0000-0003-3800-5408)
- Haiquan Chen (ORCID: https://orcid.org/0000-0003-1689-0549)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- State Key Laboratory of Genetic Engineering
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12967-025-06316-6
- Citations
- 3
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 4.56