Investigation of the relationship between serum homocysteine levels and cardiac markers and biochemical parameters in ST-elevated myocardial infarction

Although electrocardiographic changes are used widespreadly to characterize patients presenting with myocardial infarction (MI), little is known about recent incidence rates, treatment, and outcomes of patients presenting for MI, which is also stratified by ST-segment elevation (STEMI). Homocysteine (Hcy) metabolism is essential in methionine availability, protein homeostasis, and DNA methylation. Therefore, it is necessary in post-genomic and epigenetic regulation mechanisms. As a result, impaired Hcy metabolism leading to high Hcy concentrations in blood plasma (hyperhomocysteinemia) is linked to the excessive free-radical production. The aim of this study is to evaluate the relationship between routinely-measured cardiac parameters, lipid profile, homocysteine and lipoprotein (a) levels in the diagnosis of STEMI. The study subjects comprised 100 patients diagnosed with STEMI and 100 healthy individuals. Homocysteine, lipoprotein (a), cardiac parameters and routine biochemical parameters were measured in serum obtained from blood samples taken from patients and healthy individuals. The study indicates that in the patient group, leukocyte (p< 0.01), neutrophil (p< 0.01), CRP (p< 0.01), total cholesterol (p< 0.01), LDL-cholesterol (p< 0, 01) levels were found to be higher. Lymphocyte count, albumin (p< 0.05), uric acid (p< 0.01), and HDL-cholesterol (p<0.01) levels were found to be low. Again, CK (p<0.01), CK-MB (p<0.01), troponin (p<0.01), homocysteine (p< 0.01), and lipoprotein (a) (p< 0.01) levels were found to be higher in the patient group than in the control group. As a result, it can be concluded that the relationship between routinely-measured cardiac parameters, lipid profile, Homocysteine and lipoprotein (a) levels may be important in the diagnosis of STEMI, and the results obtained will make a base for further studies in this field.