FOSL1 drives the malignant progression of pancreatic cancer cells by regulating cell stemness, metastasis and multidrug efflux system
FOSL1 promote the malignant progression of pancreatic cancer by promoting HMGA1 expression. Targeting FOSL1 and HMGA1 in monotherapy or combination therapy is a promising strategy for the treatment of advanced and metastasis pancreatic cancer.
Authors
- Ye Liu (ORCID: https://orcid.org/0000-0002-8473-6538)
- Xiaolong Liu (ORCID: https://orcid.org/0000-0002-3096-4981)
- Xueyan Zhang
- Shuping Wang (ORCID: https://orcid.org/0000-0001-6433-8412)
- Yulan Li (ORCID: https://orcid.org/0000-0002-3945-2157)
- T. X. Zeng
- Yali Chen (ORCID: https://orcid.org/0000-0001-5396-9307)
Institutions
- Guizhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12967-025-06304-w
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China