Expression of MCCC2 in glioma cells and preliminary verification of poor prognosis
This investigation revealed that suppressing MCCC2 expression impedes the proliferation, migration, and invasion of GBM cells and promotes GBM cell apoptosis by curtailing ERK expression and phosphorylation. This discovery implies that MCCC2 might serve as a potential biological target for anti-GBM therapy, laying the groundwork for future research in this field.
Authors
- Chao Feng (ORCID: https://orcid.org/0000-0003-3259-562X)
- Hong‐Wei Gao (ORCID: https://orcid.org/0000-0003-1959-7452)
- Fan Yu (ORCID: https://orcid.org/0000-0003-1562-250X)
- Bowen Zhang (ORCID: https://orcid.org/0000-0003-0432-745X)
- Xiaojie Lu
Institutions
- Qingdao University (CN)
- Jiangnan University (CN)
- University Medical Center (US)
- Affiliated Hospital of Qingdao University (CN)
- Taian City Central Hospital (CN)
Publication Details
- Journal
- Biomarkers in Medicine
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1080/17520363.2025.2473131
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63