Risk factors for postoperative morbidity after ventral hernia repair in patients with liver cirrhosis. A single tertiary center cohort

<b>Introduction:</b> Ventral hernias are common among patients with liver cirrhosis.<b>Aim:</b> The aim of our work was to evaluate potential risk factors for major postoperative morbidity after ventral hernia repair in cirrhotic patients.<b>Material and methods:</b> A retrospective cohort study was performed in 45 consecutive cirrhotic patients that underwent ventral hernia repair between 2005 and 2022. Major morbidity was defined as Clavien-Dindo ≥ IIIa at 30 days postoperatively. Uni- and multivariate analysis was performed to identify risk factors for major postoperative complications.<b>Results:</b> In our cohort, we observed an overall postoperative 30-day morbidity rate of 53.33% (n = 24), with 40% (n = 18) of cases classified as Clavien-Dindo IIIa or above. Elevated serum creatinine level preoperatively was identified as a statistically significant risk factor, both in the uni- as well as the multivariate analysis for major morbidity (OR = 31.08; 95%CI [29.51-32.65]; P = 0.028).<b>Conclusions:</b> Increased creatinine levels were found to be a significant modifiable factor for major morbidity after ventral hernia repair in cases with cirrhosis. This finding underlines the impact of preoperative medical management of cirrhotic patients on postoperative outcome in this patient population.