An Integrative Clinical and Intra- and Peritumoral MRI Radiomics Nomogram for the Preoperative Prediction of Lymphovascular Invasion in Rectal Cancer

The radiomics model based on the 3 mm peritumoral region in T2WI demonstrated greater precision and sensitivity in identifying LVI. The radiomics model, which combined features from both intratumoral and peritumoral regions, exhibited superior performance compared to models based solely on either intratumoral or peritumoral attributes. The optimal combination was the integration of intratumoral features with the 3 mm peritumoral region in T2WI. A nomogram integrating radiomics features from intratumoral and peritumoral regions with clinical parameters offers valuable support for the preoperative diagnosis of LVI in RC, demonstrating significant clinical utility.