Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy

In this paper, the changes in the intestinal microbiome and plasma metabolome before and after temporary ileostomy were reported for the first time, and the dynamic changes in intestinal contents were described. At the same time, the key bacterial genera involved in the reestablishment of microflora after the restoration of intestinal continuity were found, and the key relationship between them and plasma metabolites was also found. More importantly, we found that patients with ileal fistula may be at risk of metabolic imbalance and that this particular metabolic state may potentially affect the course of tumor treatment. Finally, the samples in this study were obtained in their natural state and can be easily applied to the clinic to avoid unnecessary invasive examinations.

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Publication Details

Journal
Microbiology Spectrum
Published
2025-03-04
DOI
https://doi.org/10.1128/spectrum.01191-24
Citations
5
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
4.03
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article

Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy

Liang Tan, Guangyan Ji, Liang Xu, Anyan Liao et al.
5 citations
Microbiology Spectrum
Gut microbiota and health
4.03
article

Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy

Liang Tan, Guangyan Ji, Liang Xu, Anyan Liao, Wénwén Liú, Ying Wang, Lang Chen, Haitao Ma, Xiaolong Li, Xiao Gao, Weidong Xiao, Hua Yang, Yuan Qiu
article en
5 citations

Abstract

In this paper, the changes in the intestinal microbiome and plasma metabolome before and after temporary ileostomy were reported for the first time, and the dynamic changes in intestinal contents were described. At the same time, the key bacterial genera involved in the reestablishment of microflora after the restoration of intestinal continuity were found, and the key relationship between them and plasma metabolites was also found. More importantly, we found that patients with ileal fistula may be at risk of metabolic imbalance and that this particular metabolic state may potentially affect the course of tumor treatment. Finally, the samples in this study were obtained in their natural state and can be easily applied to the clinic to avoid unnecessary invasive examinations.

Microbiology SpectrumVol. 13(4)
Southwest University (CN), Army Medical University (CN), Dalian Medical University (CN), Second Affiliated Hospital of Chongqing Medical University (CN), The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), First People's Hospital of Chongqing (CN), Chongqing Medical University (CN)
Openalex Percentile: Top 7%
Gut microbiota and health
4.03
DOIOpen Access PDFOpenAlex
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Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy — Liang Tan, Guangyan Ji, et al. · Microbiology Spectrum (2025) | TGRS Research Map | TGRS