Microparticles zerumbone from <i>Zingiber zerumbet</i> rhizome in chitosan modified oleic acid

Abstract Zerumbone is a marker compound of Zingiber zerumbet that has antioxidant and anticancer properties. It exhibits low solubility in water, necessitating methods to enhance it has solubility, such as the creation of microparticles with chitosan in oleic acid. Therefore, this research aimed to isolate zerumbone from Z. zerumbet rhizome and determine the formation of its microparticles in chitosan in oleic acid. Zerumbone isolated by recrystallization the Z. zerumbet essential oil. Six different formulations of microparticles with chitosan (2.5–3.0 %), TPP as cross-linker, oleic acid as surfactant, and zerumbone. The formation of microparticles was analyzed using FTIR. The results showed a zerumbone yield of 0.11 % decibels. The particle size of the best microparticle was 5.516 μm, absorptive efficiency is 47 %, and amide linkages between the chitosan and oleic acid were confirmed based on FTIR. The microparticles have LC 50 value lower than native zerumbone. The zerumbone microparticles in chitosan-modified oleic acid have great potential for zerumbone delivery.