The psychedelic (−)-2,5-dimethoxy-4-iodoamphetamine [(−)-DOI] demonstrates efficacy in reducing cocaine reward and motivation in male rats
(-)-DOI 'devalued' cocaine reward and motivation to take cocaine in a 5-HT<sub>2A</sub>R-dependent manner. As serotonergic psychedelics emerge as therapeutic candidates, investigations of 5-HT<sub>2A</sub>R-acting psychedelics in preclinical analyses of cocaine intake and relapse vulnerability during abstinence will be valuable as prelude to future clinical trials.
Authors
- Noelle C. Anastasio (ORCID: https://orcid.org/0000-0001-5579-4213)
- Erik J. Garcia (ORCID: https://orcid.org/0000-0003-4760-7048)
- Joshua C. Zamora
- Kathryn A. Cunningham
- Leah M. Salinsky (ORCID: https://orcid.org/0000-0002-7065-6748)
- Christina R. Merritt (ORCID: https://orcid.org/0000-0002-8830-4863)
- Robert G. Fox
Institutions
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1007/s00213-025-06765-3
- Citations
- 6
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.84
Funders
- National Institute on Drug Abuse