Elevated plasma B<sub>12</sub> and betaine levels in women with anorexia nervosa: possible role in illness pathophysiology and epigenetic regulation
Elevated B<sub>12</sub> levels in AN resemble elevations reported among people with autoimmune, neoplastic, or other disorders. Such elevations imply that plasma B<sub>12</sub> levels may misrepresent nutritional status among people with AN. Observed associations between levels of B<sub>12</sub> and methylation at certain gene regions have ambiguous importance, but may indicate an influence of nutritional status on epigenetic mechanisms or may be the coincidence of separate processes that independently affect levels of micronutrients and DNA methylation.
Authors
- Jessica Burdo (ORCID: https://orcid.org/0000-0003-2102-5859)
- Luis B. Agellon (ORCID: https://orcid.org/0000-0002-2209-8702)
- Valérie Marcil (ORCID: https://orcid.org/0000-0002-7683-674X)
- Édith Breton (ORCID: https://orcid.org/0000-0002-8498-3133)
- Annie St‐Hilaire (ORCID: https://orcid.org/0000-0001-6491-2162)
- Mimi Israël (ORCID: https://orcid.org/0000-0003-0962-3514)
- Zsófia Nemoda (ORCID: https://orcid.org/0000-0002-9550-7730)
- Linda Booij (ORCID: https://orcid.org/0000-0002-0863-8098)
- Lea Thaler (ORCID: https://orcid.org/0000-0002-3984-1240)
- Howard Steiger (ORCID: https://orcid.org/0000-0003-4887-7824)
- Véronique Bélanger (ORCID: https://orcid.org/0000-0003-0332-7335)
- Chloé Paquin Hodge (ORCID: https://orcid.org/0000-0002-7540-9738)
- Kevin F. Casey
- Maegan Harvison
- Juliana Meyerfreund
Institutions
- Université du Québec à Chicoutimi (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- McGill University (CA)
- Toronto Metropolitan University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Journal of Psychiatry and Neuroscience
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1503/jpn.240155
- Citations
- 4
- Primary Topic
- Eating Disorders and Behaviors
- Type
- article
- Field-Weighted Citation Impact
- 9.23
Funders
- Canadian Institutes of Health Research