MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway
This study demonstrated that miR-147b-3p plays a crucial role in promoting osteogenic differentiation in osteoporotic vertebral compression fractures (OVCF) by targeting NDUFA4 and modulating the PI3K/AKT signaling pathway. These findings provide new insights into the molecular mechanisms underlying the progression of osteoporotic vertebral fractures.
Authors
- Kai Shen (ORCID: https://orcid.org/0000-0002-7772-8011)
- Yuanyuan Guo (ORCID: https://orcid.org/0000-0002-5122-8545)
- Chenchen Niu (ORCID: https://orcid.org/0000-0003-4405-9162)
- Zhenlin Li (ORCID: https://orcid.org/0000-0002-3706-4505)
- Yang Luo (ORCID: https://orcid.org/0000-0001-7477-4728)
Institutions
- Chongqing University (CN)
- Kunming Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13018-025-05598-2
- Citations
- 7
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 6.55