In vitro and in silico evaluation of synthetic compounds derived from bi-triazoles against asexual and sexual forms of Plasmodium falciparum

Overall, the in vitro and in silico results showed that bi-triazole compounds may guide new biological investigation for malaria, enabling the identification and development of more active and selective antimalarial agents.

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Publication Details

Journal
Malaria Journal
Published
2025-03-04
DOI
https://doi.org/10.1186/s12936-025-05297-7
Primary Topic
Click Chemistry and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

In vitro and in silico evaluation of synthetic compounds derived from bi-triazoles against asexual and sexual forms of Plasmodium falciparum

Sabrina Baptista Ferreira, Aurileya de Jesus Gouveia, Jansen Fernandes Medeiros, Ana Paula de Azevedo dos Santos et al.
Malaria Journal
Click Chemistry and Applications
article

In vitro and in silico evaluation of synthetic compounds derived from bi-triazoles against asexual and sexual forms of Plasmodium falciparum

Sabrina Baptista Ferreira, Aurileya de Jesus Gouveia, Jansen Fernandes Medeiros, Ana Paula de Azevedo dos Santos, Carlos R. Kaiser, Carolina Bioni Garcia Teles, Norton Rubens Diunior Lucas Pejara Rossi, Welington da Silva Paula do Nascimento, Marcinete Latorre Almeida, Saara Neri Fialho, Quelli Larissa Oliveira de Santana, Amália dos Santos Ferreira, Minelly Azevedo da Silva, Leandro do Nascimento Martinez, Maísa da Silva Araújo, Nuna Araújo
article en

Abstract

Overall, the in vitro and in silico results showed that bi-triazole compounds may guide new biological investigation for malaria, enabling the identification and development of more active and selective antimalarial agents.

Malaria JournalVol. 24(1)
Universidade Federal do Rio de Janeiro (BR), Universidade Federal de Rondônia (BR), Instituto Federal de Educação, Ciência e Tecnologia de Rondônia (BR), Centro Universitário São Lucas (BR), Fundação Oswaldo Cruz (BR)
Bill and Melinda Gates Foundation, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Ministério da Saúde, Fundação Oswaldo Cruz
Gender equality
Openalex Percentile: Top 97%
Click Chemistry and Applications
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