Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy
The shared HLA-bound neoepitopes in pancreatic ductal adenocarcinoma (PDAC) represent a novel class of noncanonical antigens with single amino acid substitutions resulting from translational errors. These peptides, shared across patients with PDAC, showed higher immunogenicity than wild-type counterparts, offering potential candidates for specific immunotherapy development in PDAC. See related article by Zhang et al., p. 1956.
Authors
- Kuirong Jiang (ORCID: https://orcid.org/0000-0002-2849-5450)
- Qun Chen (ORCID: https://orcid.org/0000-0002-9034-9825)
- Courtney W. Houchen (ORCID: https://orcid.org/0000-0003-2487-5242)
- Min Li (ORCID: https://orcid.org/0000-0002-3971-9130)
- Hao Yuan
- Yuqing Zhang (ORCID: https://orcid.org/0000-0001-8839-4849)
Institutions
- University of Oklahoma Health Sciences Center (US)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-4368
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80