Ezrin works as a scaffold protein for a macrophage checkpoint molecule CD47, leading to a poor prognosis for patients with uterine cervical squamous cell carcinoma
This study illustrates that in uterine cervical cancers, ezrin may be a dominant scaffold protein responsible for CD47 expression and, therefore, is a potential target for developing a novel macrophage checkpoint blockade therapy.
Authors
- Yoko Urashima (ORCID: https://orcid.org/0000-0001-8935-6078)
- Takuro Kobori (ORCID: https://orcid.org/0000-0001-9489-5826)
- Yui Ito (ORCID: https://orcid.org/0000-0003-0712-2513)
- Tokio Obata (ORCID: https://orcid.org/0000-0002-0878-5493)
- Kikuko Hotta (ORCID: https://orcid.org/0000-0003-2427-6354)
- Nobumasa Takagaki (ORCID: https://orcid.org/0000-0001-8300-1209)
- Takuya Ito (ORCID: https://orcid.org/0000-0001-8256-5010)
Institutions
- Osaka Ohtani University (JP)
- International Research Center for Japanese Studies (JP)
Publication Details
- Journal
- Taiwanese Journal of Obstetrics and Gynecology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.tjog.2024.12.006
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.80