Dicer Loss in Müller Glia Leads to a Defined Sequence of Pathological Events Beginning With Cone Dysfunction
MG Dicer loss in the adult mouse retina impacts cone function prior to any measurable changes in rod function, suggesting a pivotal role for MG Dicer and miRNAs in supporting cone health. A partially impaired RPE, however, seems to accelerate rod degeneration and overall degenerative events.
Authors
- S. Chen (ORCID: https://orcid.org/0009-0001-9556-1876)
- Khulan Batsuuri
- Suresh Viswanáthan (ORCID: https://orcid.org/0000-0002-7094-6980)
- Sabine Fuhrmann (ORCID: https://orcid.org/0000-0002-2456-5490)
- Stefanie G. Wohl (ORCID: https://orcid.org/0000-0003-2559-7678)
- Seoyoung Kang
- Daniel Larbi
- Alexander M. Rief
Institutions
- Indiana University Bloomington (US)
- SUNY College of Optometry (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1167/iovs.66.3.7
- Citations
- 2
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.64