Structural variants linked to Alzheimer’s disease and other common age-related clinical and neuropathologic traits
While still limited in sample size, this study highlights the utility of including analysis of SVs for elucidating mechanisms underlying GWAS loci and provides a valuable resource for the characterization of the effects of SVs in neurodegenerative disease pathogenesis.
Authors
- Shinya Tasaki (ORCID: https://orcid.org/0000-0003-3656-7394)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Ricardo A. Vialle (ORCID: https://orcid.org/0000-0003-3311-4197)
- Aron S. Buchman (ORCID: https://orcid.org/0000-0002-6426-2742)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Kátia de Paiva Lopes (ORCID: https://orcid.org/0000-0002-0240-0126)
- Bernard Ng (ORCID: https://orcid.org/0000-0002-8688-3873)
- Chris Gaiteri (ORCID: https://orcid.org/0000-0001-7838-8664)
- José M. Farfel (ORCID: https://orcid.org/0000-0003-2057-3669)
- Aliza P. Wingo (ORCID: https://orcid.org/0000-0002-6360-6726)
- Li Y (ORCID: https://orcid.org/0000-0003-1032-2292)
- Yanling Wang (ORCID: https://orcid.org/0000-0003-2012-1099)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
Institutions
- Rush University Medical Center (US)
- Emory University (US)
- SUNY Upstate Medical University (US)
- Columbia University Irving Medical Center (US)
- VA Northern California Health Care System (US)
- University of California, Davis (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13073-025-01444-6
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.15
Funders
- National Institute on Aging