5-hydroxymethylcytosine sequencing of plasma cell-free DNA identifies epigenomic features in prostate cancer patients receiving androgen deprivation therapies
5hmC-based activity scores from gene-sets involved in AR responses show great potential in assessing treatment resistance, monitoring disease progression, and identifying patients who would benefit from upfront treatment intensification. However, further studies are needed to validate these findings.
Authors
- Brandon J. Manley (ORCID: https://orcid.org/0000-0002-7927-1510)
- Qianxia Li (ORCID: https://orcid.org/0000-0002-6091-3114)
- Jodie Wong (ORCID: https://orcid.org/0009-0009-2892-2641)
- Jinyong Huang (ORCID: https://orcid.org/0000-0002-7350-6024)
- Manish Kohli (ORCID: https://orcid.org/0000-0002-9735-6614)
- Amirreza Bitaraf (ORCID: https://orcid.org/0000-0002-1495-0870)
- Manishkumar Patel (ORCID: https://orcid.org/0000-0002-7949-5610)
- Jingsong Zhang (ORCID: https://orcid.org/0000-0003-3700-151X)
- Elizabeth Gore
- Shane Huang
- Yijun Tian (ORCID: https://orcid.org/0000-0003-3471-3685)
- Deepak Kilari (ORCID: https://orcid.org/0000-0002-6999-1901)
- Jong Y. Park (ORCID: https://orcid.org/0000-0002-6384-6447)
- Chiang‐Ching Huang (ORCID: https://orcid.org/0000-0003-4251-9911)
- Marja T. Nevalainen (ORCID: https://orcid.org/0000-0003-2273-6396)
- Xiaowei Dong (ORCID: https://orcid.org/0009-0006-5266-2083)
- Liang Wang (ORCID: https://orcid.org/0000-0002-9364-8572)
Institutions
- University of Wisconsin–Madison (US)
- Thomas Jefferson University (US)
- Medical College of Wisconsin (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- Moffitt Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- Tongji Hospital (CN)
- Sidney Kimmel Comprehensive Cancer Center (US)
- University of Wisconsin–Milwaukee (US)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1038/s43856-025-00783-0
- Citations
- 5
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Institutes of Health