Copper-Mediated Phosphoniumation of Aryl/Vinyl Boronic Acids
Following the successful construction of nitrilium/pyridinium and sulfonium salts, the Chan-Lam coupling has been significantly advanced with the first demonstration of quaternary phosphonium salt synthesis. We present a method employing copper(II) acetate in trifluoroethanol to efficiently produce a range of aryl and vinyl phosphonium salts from boronic acids, including those derived from complex natural products, thus overcoming phosphine oxidation issues and expanding the scope to functionalized phosphorus.
Authors
- Xiaowen Zhan (ORCID: https://orcid.org/0000-0002-1422-6233)
- Bin Liu (ORCID: https://orcid.org/0000-0003-4365-1623)
- Zhongzheng Tian (ORCID: https://orcid.org/0009-0005-3640-2196)
- Peng Liu (ORCID: https://orcid.org/0000-0002-9850-3276)
- Zhibin Luo (ORCID: https://orcid.org/0000-0003-2105-5150)
- Chao Hu (ORCID: https://orcid.org/0009-0006-0507-7391)
- Dongchang Han
- Ao Wen
Institutions
- Jiangsu University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c00444
- Citations
- 2
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China