Association of Plasma Angiogenin With Risk of Incident End-Stage Kidney Disease in Individuals With Type 2 Diabetes
We investigated the association of plasma angiogenin with the risk of incident end-stage kidney disease (ESKD) in patients with type 2 diabetes. A high level of plasma angiogenin is independently associated with an increased risk for incident ESKD. A two-sample Mendelian randomization analysis suggested angiogenin may be causally involved in pathogenesis of chronic kidney disease. Plasma angiogenin may be a novel biomarker and potential therapeutic target for treatment of progressive kidney disease in patients with diabetes.
Authors
- Huili Zheng (ORCID: https://orcid.org/0000-0002-3976-0088)
- Keven Ang (ORCID: https://orcid.org/0000-0002-7656-2523)
- Clara C. Chan (ORCID: https://orcid.org/0000-0002-2886-2011)
- Janus Lee
- Resham L Gurung (ORCID: https://orcid.org/0000-0002-8772-4452)
- Jianjun Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
- Su Chi Lim (ORCID: https://orcid.org/0000-0002-3361-7512)
- Sylvia Liu (ORCID: https://orcid.org/0000-0001-8561-7787)
Institutions
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Khoo Teck Puat Hospital (SG)
- Duke-NUS Medical School (SG)
- Signature Research (United States) (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-03-04
- DOI
- https://doi.org/10.2337/db24-0699
- Citations
- 2
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61