Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation
Retinal dysfunction, decreased mitochondrial number, and metabolic imbalance were observed in mice with impaired peroxisomal fatty acid oxidation. Nutrient intervention may offer a promising therapeutic approach for peroxisomal diseases.
Authors
- Tori C. Rodrick (ORCID: https://orcid.org/0009-0006-6201-6579)
- Myriam Boeck (ORCID: https://orcid.org/0000-0001-8343-4426)
- Irfan J. Lodhi (ORCID: https://orcid.org/0000-0002-6246-9862)
- Zhongjie Fu (ORCID: https://orcid.org/0000-0002-8182-2983)
- Sasha A. Singh (ORCID: https://orcid.org/0000-0003-0929-3164)
- Katherine Neilsen
- Richard P. Bazinet (ORCID: https://orcid.org/0000-0002-5013-5144)
- Andrew McCutcheon
- Chuck T. Chen (ORCID: https://orcid.org/0000-0002-1099-4198)
- Deokho Lee (ORCID: https://orcid.org/0000-0002-5992-9039)
- Hitomi Yagi (ORCID: https://orcid.org/0000-0002-5199-1970)
- Masanori Aikawa (ORCID: https://orcid.org/0000-0002-9275-2079)
- Taku Kasai (ORCID: https://orcid.org/0000-0002-8075-6099)
- Yan Zeng (ORCID: https://orcid.org/0000-0002-5496-4468)
- Jeff Lee
- Miao Yu (ORCID: https://orcid.org/0009-0008-3981-7284)
- Shen Nian (ORCID: https://orcid.org/0000-0002-9684-0340)
- Chaomei Wang
- Victoria Hirst
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- University of Toronto (CA)
- Washington University in St. Louis (US)
- University Medical Center Freiburg (DE)
- Xi'an Medical University (CN)
- Xi’an Children’s Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1016/j.jare.2025.03.004
- Citations
- 3
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 2.42