Elevated CD10− neutrophils correlate with non-response and poor prognosis of CD19 CAR T-cell therapy for B-cell acute lymphoblastic leukemia
As one of the key factors in the TME, abnormally elevated CD10<sup>-</sup> neuts correlate with CAR T therapy resistance. Targeting these neutrophils could enhance the effectiveness of CAR T treatment.
Authors
- Ji Zhou (ORCID: https://orcid.org/0000-0002-1361-5421)
- Yangyang Ding (ORCID: https://orcid.org/0000-0003-1588-2571)
- Huiping Wang
- Hao Xiao (ORCID: https://orcid.org/0000-0002-7619-3115)
- Ying Pan (ORCID: https://orcid.org/0000-0001-9935-6194)
- Furun An (ORCID: https://orcid.org/0000-0003-4089-3790)
- Fan Wu (ORCID: https://orcid.org/0000-0003-1039-3752)
- Zhimin Zhai
- Jinli Zhu
- Meng Xiao (ORCID: https://orcid.org/0000-0003-4761-7756)
- Xunyi Jiao
- Xue Liang (ORCID: https://orcid.org/0000-0001-8269-0305)
- Yingwei Li (ORCID: https://orcid.org/0000-0003-4149-2462)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s12916-025-03968-5
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China