Advancing trabecular bone score (TBS): clinical performance of TBS version 4.0 with direct correction for soft tissue thickness—the osteolaus study
TBS v4.0 enhances the adjustment for regional soft tissue effects and results suggest comparable vertebral fracture risk prediction to TBS v3. Explainable AI provided insights into the contributions of BMI, tissue thickness, visceral fat, and gynoid fat to the observed changes between TBS versions. Incorporating direct tissue thickness adjustment improves TBS applicability across diverse body sizes and compositions.
Authors
- Elena González Rodríguez (ORCID: https://orcid.org/0000-0001-6512-6008)
- Karen Hind (ORCID: https://orcid.org/0000-0002-4546-5536)
- Olivier Lamy (ORCID: https://orcid.org/0000-0003-3684-2376)
- Didier Hans (ORCID: https://orcid.org/0000-0003-1826-5958)
- Enisa Shevroja (ORCID: https://orcid.org/0000-0001-6338-2948)
- Guillaume Gatineau (ORCID: https://orcid.org/0000-0002-8440-391X)
Institutions
- Durham University (GB)
- L.A.C. (Switzerland) (CH)
- Lancaster University (GB)
- University of Lausanne (CH)
Publication Details
- Journal
- Osteoporosis International
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1007/s00198-025-07421-4
- Citations
- 8
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 13.77
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois