Super Methotrexate-resistant Osteosarcoma Cells Retain Their Sensitivity to Recombinant Methioninase: Targeting Methionine Addiction to Overcome Extreme Cancer-Chemotherapy Resistance
rMETase overcame a 5,500-fold MTX-resistance of osteosarcoma cells. The present results suggest methionine restriction by rMETase can be a potential clinical strategy to overcome recalcitrant drug-resistance in osteosarcoma.
Authors
- Yutaro Kubota (ORCID: https://orcid.org/0000-0002-2917-8764)
- Yasunori Tome (ORCID: https://orcid.org/0000-0002-3716-1866)
- Kotaro Nishida (ORCID: https://orcid.org/0000-0002-1279-2717)
- Michael Bouvet (ORCID: https://orcid.org/0000-0002-0086-2159)
- Robert M. Hoffman (ORCID: https://orcid.org/0000-0002-0049-0041)
- NORIYUKI MASAKI (ORCID: https://orcid.org/0000-0002-0463-9608)
- YUSUKE AOKI (ORCID: https://orcid.org/0000-0002-1701-9678)
- Qinghong Han
Institutions
- University of the Ryukyus (JP)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.21873/anticanres.17480
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00