The Appropriate Conditions for the Cell Sparing (FLASH) Effect Exist in Ultra-high Dose Rate Carbon Ion Irradiation
Carbon ion uHDR irradiation induces a cell-sparing effect under normoxic conditions, which is influenced by LET and oxygen concentration. These findings provide essential insights into the mechanisms underlying the FLASH effect and pave the way for advancing the clinical application of uHDR carbon ion therapy.
Authors
- Masashi Yagi (ORCID: https://orcid.org/0000-0002-2827-5407)
- Kazuki Fujita (ORCID: https://orcid.org/0000-0003-0332-5831)
- Jiro Fujimoto (ORCID: https://orcid.org/0000-0002-2757-9011)
- TOSHIRO TSUBOUCHI
- Takuya Nomura (ORCID: https://orcid.org/0000-0001-9911-3619)
- Yoshiaki Kuwana
- Masaki Shimizu (ORCID: https://orcid.org/0000-0003-1077-7772)
- Noriaki Hamatani
- Masaaki Takashina
- Kazumasa Minami (ORCID: https://orcid.org/0000-0002-3864-6478)
- Katsura Nagata
- Shinichi Shimizu (ORCID: https://orcid.org/0000-0003-3143-0479)
- Kazuhiko Ogawa (ORCID: https://orcid.org/0000-0001-8872-7690)
- Ryo Hidani
- Masumi Umezawa
Institutions
- Hitachi (Japan) (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.21873/anticanres.17483
- Citations
- 4
- Primary Topic
- Radiation Effects in Electronics
- Type
- article
- Field-Weighted Citation Impact
- 2.92