Peripheral CD4<sup>+</sup>T Cells Predict T Cell Immunity in Lung Tissues of Non-small Cell Lung Cancer Patients
Patients with NSCLC with a high percentage of the peripheral CD4<sup>+</sup> T cell subset are at an increased risk of anti-PD-1-related pneumonitis, which activates PD-1<sup>+</sup>CD4<sup>+</sup> T cells in the absence of the suppressive activity of effector Treg cells in lung tissues.
Authors
- Hisashi Wada (ORCID: https://orcid.org/0000-0002-5444-6193)
- Mari Tone (ORCID: https://orcid.org/0000-0002-8230-0757)
- Atsushi Kumanogoh (ORCID: https://orcid.org/0000-0003-4749-7117)
- Kota Iwahori (ORCID: https://orcid.org/0000-0002-9891-6003)
- Yoshito Takeda (ORCID: https://orcid.org/0000-0003-2905-6537)
- Yasushi Shintani (ORCID: https://orcid.org/0000-0002-2540-5288)
- Tomomi Isono (ORCID: https://orcid.org/0000-0002-0652-2331)
- Yoko Yamamoto (ORCID: https://orcid.org/0000-0003-3190-4427)
Institutions
- Japan Agency for Medical Research and Development (JP)
- Osaka International Cancer Institute (JP)
- Osaka International University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.21873/anticanres.17478
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09