Evaluation of the Therapeutic Potential of DPP4 Inhibitor in Upper Tract Urothelial Carcinoma Cells
Sitagliptin inhibits the proliferation and migration of UTUC cells, promotes apoptosis, and influences the phenotypical transition from mesenchymal to epithelial states, likely <i>via</i> modulation of the AKT pathway. Sitagliptin may not cause chemotherapy resistance when combined with cisplatin treatment. These findings highlight its potential as an adjuvant therapy in UTUC.
Authors
- Hao‐Lun Luo (ORCID: https://orcid.org/0000-0002-5988-0474)
- Y.-C. Liu
- H.-M. Liu
- Yao‐Lung Chang (ORCID: https://orcid.org/0000-0003-2025-5492)
- Yen-Ting Wu (ORCID: https://orcid.org/0000-0003-0096-7986)
Institutions
- Kaohsiung Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.21873/anticanres.17487
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05