Highly Synergistic Eradication of 143B Osteosarcoma Cells<i>In Vitro</i>by the Combination of Recombinant Methioninase, Chloroquine, and Rapamycin Targeting Methionine Addiction, Autophagy, and mTOR, Respectively
The triple combination of rMETase, CQ, and RAPA demonstrated strong synergy and effectively eradicated 143B osteosarcoma cells. Therefore, the triple treatment with rMETase, CQ, and RAPA has potential as a novel, effective therapeutic approach for osteosarcoma.
Authors
- Michael Bouvet (ORCID: https://orcid.org/0000-0002-0086-2159)
- Shinji Miwa (ORCID: https://orcid.org/0000-0002-5962-8287)
- Byung Mo Kang (ORCID: https://orcid.org/0000-0003-0900-094X)
- Katsuhiro Hayashi (ORCID: https://orcid.org/0000-0001-8665-2154)
- Norio Yamamoto (ORCID: https://orcid.org/0000-0002-0622-5441)
- Takashi Higuchi (ORCID: https://orcid.org/0000-0003-2896-4939)
- Hiroyuki Tsuchiya (ORCID: https://orcid.org/0000-0003-0730-7921)
- KOHEI MIZUTA
- Satoru Demura
- Kentaro Igarashi (ORCID: https://orcid.org/0000-0003-2278-1736)
- Sei Morinaga (ORCID: https://orcid.org/0000-0003-2961-9432)
- Hiroaki Kimura (ORCID: https://orcid.org/0000-0003-2145-8726)
- Robert M. Hoffman
- Qinghong Han
Institutions
- Kanazawa University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.21873/anticanres.17481
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00