Polygenic Resilience Scores are Associated With Lower Penetrance of Schizophrenia Risk Genes, Protection Against Psychiatric and Medical Disorders, and Enhanced Mental Well-Being and Cognition
Overall, this study highlights a wide range of phenotypes that are significantly associated with resilience loci within the general population, revealing distinct patterns separate from those associated with SCZ risk loci. Resilience loci may protect against serious psychiatric and medical outcomes, comorbidities, and cognitive impairment. Therefore, it is conceivable that resilience loci facilitate adaptive processes linked to improved health and life expectancy.
Authors
- Jiahui Hou (ORCID: https://orcid.org/0000-0002-3340-8585)
- Stephen V. Faraone (ORCID: https://orcid.org/0000-0002-9217-3982)
- Eric J. Barnett (ORCID: https://orcid.org/0000-0003-2493-2251)
- Stephen J. Glatt (ORCID: https://orcid.org/0000-0002-0360-7567)
- Jonathan Hess (ORCID: https://orcid.org/0000-0001-8406-632X)
Institutions
- University of Pittsburgh (US)
- SUNY Upstate Medical University (US)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1093/schbul/sbae210
- Citations
- 1
- Primary Topic
- Resilience and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 0.64
Funders
- National Institutes of Health
- National Institute of Mental Health