Cardiopulmonary exercise testing as an integrative approach to explore physiological limitations in Duchenne muscular dystrophy
Valid CPET is feasible in DMD, revealing low VO<sub>2</sub> peak due to abnormal muscle metabolic and cardiorespiratory responses during dynamic exercise. CPET reveals cardiorespiratory limitations in DMD boys with unremarkable 6MWD, and should be considered an integrative approach in clinical care and assessment of emerging therapeutics.
Authors
- Manuela Corti (ORCID: https://orcid.org/0000-0002-6391-4139)
- Claire Cousins (ORCID: https://orcid.org/0000-0001-6478-8552)
- Wei Xue (ORCID: https://orcid.org/0000-0003-1568-4946)
- Tina Duong (ORCID: https://orcid.org/0000-0003-3177-4722)
- Joseph F. Russo (ORCID: https://orcid.org/0009-0009-7129-5807)
- Sean C. Forbes (ORCID: https://orcid.org/0000-0002-5258-8104)
- Donovan J. Lott (ORCID: https://orcid.org/0000-0002-9072-8630)
- Renata Shih (ORCID: https://orcid.org/0000-0001-5213-9301)
- Jeffrey W. Christle (ORCID: https://orcid.org/0000-0002-3321-6284)
- Barry J. Byrne
- Julie Berthy
- Tanja Taivassalo (ORCID: https://orcid.org/0000-0001-8923-2921)
- Carmen Leon‐Astudillo (ORCID: https://orcid.org/0000-0003-1800-4301)
- James R. May (ORCID: https://orcid.org/0000-0003-4202-1670)
- A. Pant
- John‐Anthony Coppola (ORCID: https://orcid.org/0009-0009-4291-4373)
- Meghana Bomma
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University of Florida (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Neuromuscular Diseases
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1177/22143602251319170
- Citations
- 1
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 2.38