Impact of tumor and node stages on the efficacy of adjuvant oxaliplatin-based chemotherapy in stage III colon cancer patients: an ACCENT pooled analysis
Our analysis revealed that oxaliplatin-based chemotherapy offers a significant survival benefit in stage III CC patients with T3 tumors. In contrast, no survival benefit was observed for T1-2 or T4 patients. These results suggested that T stage plays a more crucial role than N stage in predicting treatment benefit, highlighting the need for tailored treatment strategies based on tumor characteristics.
Authors
- Rachel Kerr (ORCID: https://orcid.org/0000-0002-7240-3269)
- Daniel G. Haller (ORCID: https://orcid.org/0000-0001-9549-8742)
- Benoist Chibaudel (ORCID: https://orcid.org/0000-0003-1279-2044)
- Thomas J. George (ORCID: https://orcid.org/0000-0002-6249-9180)
- T. Yoshino
- Qian Shi (ORCID: https://orcid.org/0000-0002-4640-8832)
- Romain Cohen (ORCID: https://orcid.org/0000-0001-9602-5162)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Aimery de Gramont (ORCID: https://orcid.org/0000-0001-7940-9877)
- Norman Wolmark (ORCID: https://orcid.org/0000-0001-7156-1110)
- Greg Yothers (ORCID: https://orcid.org/0000-0002-7965-7333)
- Jean‐Baptiste Bachet (ORCID: https://orcid.org/0000-0003-4337-286X)
- Morteza Raeisi (ORCID: https://orcid.org/0000-0002-9999-4097)
- Einat Shacham‐Shmueli (ORCID: https://orcid.org/0000-0001-7040-2062)
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- Richard M. Goldberg (ORCID: https://orcid.org/0000-0003-0308-8223)
- Hans‐Joachim Schmoll (ORCID: https://orcid.org/0000-0001-8705-0593)
Institutions
- Twitter (United States) (US)
- West Virginia University (US)
- Inserm (FR)
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- West Virginia University Hospitals (US)
- Sorbonne Université (FR)
- University of Oxford (GB)
- La Ligue Contre le Cancer (FR)
- Fondation FondaMental (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Antoine (FR)
- Istituto Oncologico Veneto (IT)
- Pitié-Salpêtrière Hospital (FR)
- Centre de Recherche Saint-Antoine (FR)
- Institut Hospitalier Franco Britannique (FR)
- National Cancer Center Hospital East (JP)
- Mayo Clinic in Florida (US)
- NSABP Foundation (US)
- Martin Luther University Halle-Wittenberg (DE)
- University of Pennsylvania (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104481
- Citations
- 1
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05