Phenotypic heterogeneity in mortality and prognosis of pulmonary alveolar proteinosis: a large-scale, global pooled analysis of individual-level data
This study comprehensively describes the clinical characteristics cause of death, prognosis and associated factors based on the global PAP population. The significant phenotype heterogeneity highlighting the importance of long-term prognosis and individualized management for patients with PAP.
Authors
- Ailing Duan
- Shuojia Xie
- Weizhan Luo (ORCID: https://orcid.org/0009-0006-7394-9382)
- Zhiyong Xu (ORCID: https://orcid.org/0000-0001-9873-8617)
- Liu He (ORCID: https://orcid.org/0000-0002-1349-5343)
- Ziwen Zheng (ORCID: https://orcid.org/0000-0003-1711-6328)
- Xinyu Song (ORCID: https://orcid.org/0000-0003-3158-8663)
- Zhongbiao Wu (ORCID: https://orcid.org/0000-0003-0182-5971)
- Zikai Lin (ORCID: https://orcid.org/0000-0002-0247-8628)
- Junfeng Huang (ORCID: https://orcid.org/0000-0003-0984-9505)
- Jiaming Guo (ORCID: https://orcid.org/0000-0002-2949-1398)
- Zhe Xu (ORCID: https://orcid.org/0000-0002-6675-1398)
- Jinsheng Lin
- Gengjia Chen (ORCID: https://orcid.org/0009-0005-7024-3598)
- Yuewen Gao
- Shiyue Li (ORCID: https://orcid.org/0000-0002-2431-5504)
- Jingyan Chen (ORCID: https://orcid.org/0009-0008-5332-2077)
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13023-025-03617-3
- Citations
- 3
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China