PERK+ Macrophages Drive Immunotherapy Resistance in Lymph Node Metastases of Oral Squamous Cell Carcinoma
Our study confirms that the pathologic response of LN metastases in patients with OSCC undergoing neoadjuvant immunotherapy or immunochemotherapy is inferior to that of PTs. It suggests that targeting the PERK pathway in macrophages could be a potential strategy to enhance treatment outcomes.
Authors
- Jia-Jie Liang
- Bo-Lin Xiao (ORCID: https://orcid.org/0000-0002-3363-5956)
- Jun Jia (ORCID: https://orcid.org/0000-0002-9593-5567)
- Bing Liu (ORCID: https://orcid.org/0000-0002-2103-5494)
- Yuying Zhang (ORCID: https://orcid.org/0000-0002-6181-0379)
- Lin‐Zhou Zhang (ORCID: https://orcid.org/0000-0001-7688-9297)
- Zi‐Li Yu (ORCID: https://orcid.org/0000-0003-0728-8564)
- Kui-Ming Wang (ORCID: https://orcid.org/0000-0003-2660-2280)
- Gao Zhang (ORCID: https://orcid.org/0000-0001-8617-8886)
- Yu-Tong Liu
- Zhe Shao (ORCID: https://orcid.org/0000-0003-2357-3760)
- Qiu-Yun Fu
- Gang Chen (ORCID: https://orcid.org/0000-0003-3332-3511)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-5551-2052)
- Jun Zeng
- Hai-Ming Liu (ORCID: https://orcid.org/0000-0002-2287-6519)
- Jiali Zhang (ORCID: https://orcid.org/0000-0003-0965-3027)
- Xiaoxia Cheng
- Xuepeng Xiong
- Y Wang
- Jinbang Li
- Yang-Ying-Fan Feng
- Jing Li (ORCID: https://orcid.org/0009-0000-6253-6423)
- Xinxin Wang (ORCID: https://orcid.org/0009-0006-6924-745X)
Institutions
- Wuhan University (CN)
- Stomatology Hospital (CN)
- Wuhan University of Science and Technology (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3135
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99