The synergistic effect of the combination of polymyxin B and rifampicin in a murine neutropenic thigh infection model with <i>E. coli</i> and <i>K. pneumoniae</i>
These in vivo studies confirmed that there is a clear synergistic effect between polymyxin B and rifampicin, which was stronger for the K. pneumoniae strain than for the E. coli strain.
Authors
- Sanne van den Berg (ORCID: https://orcid.org/0000-0001-9209-0178)
- William Couet (ORCID: https://orcid.org/0000-0002-7116-8965)
- Anouk E. Muller (ORCID: https://orcid.org/0000-0001-5042-6251)
- Joseph Meletiadis (ORCID: https://orcid.org/0000-0002-8869-1509)
- Sandrine Marchand (ORCID: https://orcid.org/0000-0001-5279-6678)
- Heleen van der Spek
- Sebastiaan D. T. Sassen (ORCID: https://orcid.org/0000-0002-4525-638X)
- Marian T. ten Kate
Institutions
- Inserm (FR)
- National and Kapodistrian University of Athens (GR)
- Erasmus MC (NL)
- Université de Poitiers (FR)
- GGD Haaglanden (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1093/jac/dkaf056
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Joint Programming Initiative on Antimicrobial Resistance
- ZonMw