Increased Cerebrospinal Fluid Angiotensin-Converting Enzyme 2 Fragments as a Read-Out of Brain Infection in Patients With COVID-19 Encephalopathy
Patients with encephalitis displayed an overall increase in CSF ACE2, probably as a consequence of brain inflammation. The increase of the shortest ACE2 fragment only in CoV-Enceph patients may reflect the enhanced cleavage of the receptor triggered by SARS-CoV-2, thus serving to monitor brain penetrance of the virus associated with the rare encephalitis complication. TMPRSS2 changes in the CSF appeared related to inflammation, but not with SARS-CoV-2 infection.
Authors
- Valeria De Giuli (ORCID: https://orcid.org/0000-0002-1445-1908)
- Javier Sáez‐Valero (ORCID: https://orcid.org/0000-0001-7480-320X)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- María‐Salud García‐Ayllón (ORCID: https://orcid.org/0000-0001-5140-9752)
- Andrea Pilotto (ORCID: https://orcid.org/0000-0003-2029-6606)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Davide Arici
- Chiara Tolassi (ORCID: https://orcid.org/0009-0006-8741-1313)
- Virginia Quaresima (ORCID: https://orcid.org/0000-0001-8858-3236)
- Irene Volonghi (ORCID: https://orcid.org/0000-0002-6864-1475)
- Sérgio Ferrari (ORCID: https://orcid.org/0000-0003-3855-5135)
- Viviana Cristillo
- Matthew P. Lennol (ORCID: https://orcid.org/0000-0002-4021-181X)
- Sara Mariotto (ORCID: https://orcid.org/0000-0002-7806-3103)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Gianluigi Zanusso (ORCID: https://orcid.org/0000-0001-5199-6264)
- Francesca Caprioli
- Alessandro Padovani (ORCID: https://orcid.org/0000-0002-0119-3639)
- Chiara Trasciatti
- Carlos Avilés-Granados (ORCID: https://orcid.org/0000-0001-5966-6737)
Institutions
- University of Verona (IT)
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- King's College London (GB)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Brescia University (US)
- National Institute for Health and Care Excellence (GB)
- Centre for Mental Health (GB)
- National Institute for Health and Care Research (GB)
- Sorbonne Université (FR)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto de Neurociencias (ES)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Institut de Myologie (FR)
- Centro de Investigación Biomédica en Red (ES)
- Hospital General Universitario de Elche (ES)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Azienda Socio Sanitaria Territoriale Lariana (IT)
- Banner Sun Health Research Institute (US)
- Wisconsin Division of Public Health (US)
- Institut du Cerveau (FR)
- Istituti Ospitalieri di Cremona (IT)
- Azienda Socio Sanitaria Territoriale di Cremona
- University College London (GB)
- University of Brescia (IT)
- University of Gothenburg (SE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1093/infdis/jiaf093
- Citations
- 6
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- Alzheimer's Association
- American Concrete Institute Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Ministero della Salute
- Generalitat Valenciana
- Hjärnfonden
- Vetenskapsrådet
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación
- Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana
- H2020 Marie Skłodowska-Curie Actions