Subclinical Primary Aldosteronism Is Characterized by Maladaptive Natriuretic Peptide and Adrenal Hormonal Physiology
These findings demonstrate that the pathophysiologic continuum of subclinical PA in normotensive people is characterized by natriuretic peptide insufficiency and heightened aldosterone responses to both AngII and ACTH. These early maladaptive hormonal changes provide mechanistic explanations for the role of subclinical PA in the pathogenesis of hypertension.
Authors
- Stéfanie Parisien‐La Salle (ORCID: https://orcid.org/0000-0001-5960-4181)
- Shant H. Mahrokhian (ORCID: https://orcid.org/0000-0003-4094-8739)
- Brooke Honzel (ORCID: https://orcid.org/0009-0005-2824-903X)
- Anand Vaidya (ORCID: https://orcid.org/0000-0002-0314-9252)
- Isabelle Hanna (ORCID: https://orcid.org/0009-0009-5968-1406)
- Jenifer M. Brown (ORCID: https://orcid.org/0000-0002-6647-639X)
- Thomas J. Wang (ORCID: https://orcid.org/0000-0003-4063-6508)
- Laura C Tsai (ORCID: https://orcid.org/0009-0008-5344-2589)
- Andrew J Newman (ORCID: https://orcid.org/0000-0002-8326-1964)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1210/clinem/dgaf129
- Citations
- 9
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 11.65