Proteomic analysis of plasma and urine for efficacy prediction biomarkers of Janus kinase inhibitors combined with phototherapy in vitiligo
The combination of Janus kinase inhibitors and narrowband ultraviolet B (NB-UVB) therapy is an effective treatment for vitiligo; however, reliable and convenient biomarkers for predicting treatment efficacy prior to therapy are currently lacking. The biomarker combination of pretreatment plasma C–C motif chemokine 5 and fibrinogen-like protein 1 levels, along with urine ezrin and glyceraldehyde 3-phosphate dehydrogenase levels, can predict the sensitivity to baricitinib combined with NB-UVB therapy in patients with vitiligo.
Authors
- Shiyu Zhang (ORCID: https://orcid.org/0000-0003-0923-800X)
- Tao Wang (ORCID: https://orcid.org/0000-0003-1225-0173)
- Jianqiang Wu (ORCID: https://orcid.org/0000-0001-6773-9289)
- Li Wen (ORCID: https://orcid.org/0000-0002-2621-0239)
- Lu Yang (ORCID: https://orcid.org/0000-0002-4286-9586)
- Yuehua Liu (ORCID: https://orcid.org/0000-0002-2660-0675)
- Zhonghui Hu (ORCID: https://orcid.org/0000-0002-0838-7559)
- Lu Lu (ORCID: https://orcid.org/0000-0002-0960-1529)
- Jindi Feng
- Huimin He
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- National Clinical Research (US)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1093/bjd/ljaf079
- Citations
- 2
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 2.30