Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans
This is the first study demonstrating that a biologically active dose of kisspeptin to men and women does not affect behavioral, biochemical, or physiological measures of anxiety. Given that animal studies have yielded contradictory results, this provides key clinical data and reassurance that kisspeptin does not induce anxiety in humans and so informs the current development of kisspeptin-based therapeutics for common reproductive and psychosexual disorders.
Authors
- Natalie Ertl (ORCID: https://orcid.org/0000-0002-9010-1870)
- Paul Bech
- Chioma N. Izzi‐Engbeaya (ORCID: https://orcid.org/0000-0001-7599-0166)
- Layla Thurston (ORCID: https://orcid.org/0000-0001-5120-9216)
- Edouard Mills (ORCID: https://orcid.org/0000-0002-8937-6463)
- Alexander Comninos (ORCID: https://orcid.org/0000-0002-7104-2297)
- Maria Phylactou (ORCID: https://orcid.org/0000-0002-0464-5768)
- Waljit S. Dhillo (ORCID: https://orcid.org/0000-0001-5950-4316)
- Tia Hunjan (ORCID: https://orcid.org/0000-0001-6385-1222)
- Ali Abbara (ORCID: https://orcid.org/0000-0003-2795-5256)
- Bijal Patel (ORCID: https://orcid.org/0000-0002-1709-2410)
- Megan Young (ORCID: https://orcid.org/0000-0001-7777-3966)
- Matthew B. Wall (ORCID: https://orcid.org/0000-0002-0493-6274)
- Sophie Clarke (ORCID: https://orcid.org/0000-0002-5426-2941)
- Jovanna Tsoutsouki (ORCID: https://orcid.org/0000-0001-5496-2393)
- Lisa Yang
Institutions
- Imperial College Healthcare NHS Trust (GB)
- Hammersmith Hospital (GB)
- Perceptive Engineering (United Kingdom) (GB)
- Imperial College London (GB)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1210/clinem/dgaf128
- Citations
- 1
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Medical Research Council