Natural product Pulsatilla saponin D sensitizes BRCA-proficient ovarian cancers to PARP inhibitors through inhibiting homologous recombination repair
In summary, our study found Pulsatilla Saponin D is a novel HR repair inhibitor and would optimize clinical application of PARP inhibitors on cancer patients with WT BRCA1/2.
Authors
- Yongzhu Liu (ORCID: https://orcid.org/0000-0002-9205-3841)
- Shengbin Lin (ORCID: https://orcid.org/0000-0002-2797-5452)
- Guo Chen (ORCID: https://orcid.org/0000-0001-8886-1873)
- Qin Yu (ORCID: https://orcid.org/0000-0002-4342-9398)
- Yin Zhu (ORCID: https://orcid.org/0000-0002-7561-2306)
- Binghe Sun
- Nan Yao (ORCID: https://orcid.org/0000-0001-9161-1058)
- Yi Huang
Institutions
- Jiangsu University (CN)
- Sun Yat-sen University (CN)
- China Pharmaceutical University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1093/jpp/rgaf006
- Citations
- 2
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province