Preclinical <i>in vitro</i> and <i>in vivo</i> evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas
CD74 is expressed in common CTCL subtypes. Targeting CD74 efficiently killed CTCL cells in vitro and in vivo. We therefore suggest the targeting of CD74 to be a highly promising treatment strategy for CTCL.
Authors
- Chalid Assaf (ORCID: https://orcid.org/0000-0002-7898-9432)
- Stephan Forchhammer (ORCID: https://orcid.org/0000-0002-1274-2613)
- Menghong Yin (ORCID: https://orcid.org/0000-0002-2694-0848)
- Christian M. Schürch (ORCID: https://orcid.org/0000-0002-1792-1768)
- Anja Fischer (ORCID: https://orcid.org/0000-0002-7145-2544)
- Florian Reisinger
- Falko Fend (ORCID: https://orcid.org/0000-0002-5496-293X)
- Sophie Edtmayer (ORCID: https://orcid.org/0000-0002-8896-436X)
- Jan P. Nicolay (ORCID: https://orcid.org/0000-0003-0220-0551)
- Mariantonia Costanza (ORCID: https://orcid.org/0000-0002-8959-1083)
- Agnieszka Witalisz‐Siepracka (ORCID: https://orcid.org/0000-0003-0237-0745)
- Lukas Kenner (ORCID: https://orcid.org/0000-0003-2184-1338)
- Ann‐Christin von Brünneck (ORCID: https://orcid.org/0000-0003-4371-4292)
- Olaf Merkel (ORCID: https://orcid.org/0000-0001-5089-344X)
- Gang Yin (ORCID: https://orcid.org/0000-0002-0839-242X)
- Catello Giordano
- Martin Janz (ORCID: https://orcid.org/0000-0002-1127-0044)
- Katharina Vinh
- Jürgen Christian Becker (ORCID: https://orcid.org/0000-0001-9183-653X)
- Ahmad Makky (ORCID: https://orcid.org/0000-0002-4205-1303)
- David Horst (ORCID: https://orcid.org/0000-0003-4755-5743)
- Dagmar Stoiber (ORCID: https://orcid.org/0000-0002-8824-0767)
- Stephan Mathas (ORCID: https://orcid.org/0000-0001-9626-1413)
- Ivonne A. Montes‐Mojarro (ORCID: https://orcid.org/0000-0003-0636-7623)
- Jing Zhao (ORCID: https://orcid.org/0000-0001-9464-0735)
- R. Siebert
Institutions
- Manpower Demonstration Research Corporation (US)
- University of Veterinary Medicine Vienna (AT)
- German Cancer Research Center (DE)
- Universität Ulm (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Humboldt-Universität zu Berlin (DE)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- Comprehensive Cancer Center Vienna (AT)
- Helios Klinikum Krefeld (DE)
- Christian Doppler Laboratory for Thermoelectricity (AT)
- Essen University Hospital (DE)
- Karl Landsteiner University of Health Sciences (AT)
- Sutro Biopharma (United States) (US)
- University Medical Centre Mannheim (DE)
- Medical University of Vienna (AT)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Umeå University (SE)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1093/bjd/ljaf001
- Citations
- 4
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Vienna Science and Technology Fund
- Eberhard Karls Universität Tübingen
- Bundesministerium für Bildung und Forschung
- Austrian Science Fund
- Swiss Cancer Research Foundation
- Bundesinstitut für Risikobewertung
- Medizinischen Fakultät, Eberhard Karls Universität Tübingen