Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination
Our study suggested that TZP attenuated oxidative stress and cardiomyocyte apoptosis by modulating HRD1-mediated Nrf2 expression and activity, thereby protecting against the cardiotoxic effects exerted by DOX. These results supported that TZP might be a promising therapeutic option for reducing chemotherapy-related cardiotoxicity.
Authors
- Yanghao Chen
- Zhiyu Ling (ORCID: https://orcid.org/0000-0003-1138-9528)
- Dan Yang (ORCID: https://orcid.org/0000-0001-9597-3590)
- Yi Zeng (ORCID: https://orcid.org/0000-0002-5477-6686)
- Yan-Kun Chen
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- International Neuromodulation Society (US)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1093/cvr/cvaf033
- Citations
- 9
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 12.49
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Natural Science Foundation of Chongqing