Maternal immune activation elicits rapid and sex-dependent changes in gene expression and vascular dysfunction in the rat placenta
PolyI:C elicited a powerful inflammatory response in the placenta along with vascular dysfunction, likely contributing to the adverse pregnancy outcomes triggered by MIA. Female placentas responded to PolyI:C more vigorously than male placentas, which could underlie the differential outcomes of MIA depending on sex.
Authors
- Nagalingam Rajakumar
- Ruth Thomas (ORCID: https://orcid.org/0000-0002-8316-2616)
- Stephen J. Renaud (ORCID: https://orcid.org/0000-0001-7257-5354)
- Gargi Jaju Bhattad
- Erin Biggar
- Megan L Lave
Institutions
- Western University (CA)
- London Health Sciences Centre (CA)
Publication Details
- Journal
- Placenta
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.placenta.2025.03.001
- Citations
- 1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada