TGFβ1 generates a pro-fibrotic proteome in human lung parenchyma that is sensitive to pharmacological intervention
A pro-fibrotic proteome is induced in human lung parenchyma exposed to TGFβ1, sensitive to pharmacological intervention. This approach has the potential to enhance therapeutic drug screening for IPF treatment.
Authors
- Katy M. Roach (ORCID: https://orcid.org/0000-0002-4825-8719)
- Hilary Marshall
- Peter Bradding (ORCID: https://orcid.org/0000-0001-8403-0319)
- Panayiota Stylianou (ORCID: https://orcid.org/0000-0002-0904-6043)
- Donald J. L. Jones (ORCID: https://orcid.org/0000-0001-6583-870X)
- Colleen B. Maxwell (ORCID: https://orcid.org/0000-0003-4463-3566)
- Leong L. Ng (ORCID: https://orcid.org/0000-0002-6553-5749)
- Paulene A. Quinn
- Alfie J Hall
Institutions
- University of Leicester (GB)
- Glenfield Hospital (GB)
- NIHR Leicester Cardiovascular Biomedical Research Unit (GB)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1016/j.ejphar.2025.177461
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04